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KMID : 0378019840270020088
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New Medical Journal
1984 Volume.27 No. 2 p.88 ~ p.92
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The Experimental Study for the Effect of Keto-profen Treatment on the Dermal Microcirculation after Burning in the Rate
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Abstract
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In all skin burns, there exists a zone of stasis which is not immediately coagulated but which shows a progressive compromise in microvascular circulation with a complete cessation of dermal perfusion by 24 hours. Ketoprofen(as a prostaglandin antagonist) intramuscular injection treatment was evaluated for their ability to prevent dermal ischemia in standardized partial thickness burnes in the rats.
The results of experiments as follows;
1) In untreated group, the perfusion only up to the level of the dermal plexus was shown at 12 hours and there was no dermal perfusion of the India-ink at 24 hours.
2) Ketoprofen intramuscular injection group maintained perfusion up to sub papillary plexus by 24 hours.
3) It appears from these studies that the ketoprofen intramuscular injection treatment after burning may be effective in preventing the progressive change and in improving dermal perfusion. So these treatments may lead to lessening the depth and amount of skin necrosis after a burn.
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